MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene — one of the few known mitochondrially-derived peptides — and is studied for its role in metabolic regulation and exercise mimicry. Research-grade specs Sequence length: 16 amino acids Source: Mitochondrial 12S rRNA-encoded Class: Mitochondrial-derived peptide (MDP) Discovery: 2015 Studied applications Mitochondrial signaling research Insulin sensitivity and glucose metabolism studies Exercise-mimetic research Aging-related metabolic decline studies Quality & trust ≥99% HPLC purity, third-party tested Mass spectrometry identity confirmation LAL endotoxin testing on every batch Batch-specific Certificate of Analysis included USA same-day shipping (orders before 2pm CT M-F) Related research: NAD Research literature MOTS-c has been the subject of 232 peer-reviewed publications indexed in PubMed. Selected recent literature for research reference: Mendias CL et al. (2026). Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. Sports Med. PMID: 41966639 Filibeli BE et al. (2026). Are serum MOTS-c levels and MOTS-c m.1382A>C polymorphism related to polycystic ovary syndrome?. Arch Endocrinol Metab. PMID: 41945630 Feng Z et al. (2026). MOTS-c attenuates cardiac dysfunction following high altitude exposure by promoting mitophagy. Free Radic Biol Med. PMID: 41654147 Liu S et al. (2026). Mitochondrial-derived peptide MOTS-c targets SLC7A11 to preserve spermatogenesis by suppressing ferroptosis. Free Radic Biol Med. PMID: 41933740 Chen D et al. (2026). Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway. Eur J Pharmacol. PMID: 41802484 References are provided for research reference only. Inclusion of literature does not constitute a recommendation, endorsement, or claim for any specific use of LiveWell Peptides products. Products are sold for laboratory and research use only and are not intended for human consumption, injection, topical application, or any other administration to the human body.

